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BATF-dependent IL-7RhiGM-CSF+ T cells control intestinal graft-versus-host disease

Ullrich, Evelyn ; Abendroth, Benjamin ; Rothamer, Johanna ; Huber, Carina ; Büttner-Herold, Maike ; Buchele, Vera ; Vogler, Tina ; Longerich, Thomas ; Zundler, Sebastian ; Völkl, Simon ; Beilhack, Andreas ; Rose-John, Stefan ; Wirtz, Stefan ; Weber, Georg F. ; Ghimire, Sakhila ; Kreutz, Marina ; Holler, Ernst ; Mackensen, Andreas ; Neurath, Markus F. ; Hildner, Kai



Abstract

Acute graft-versus-host disease (GVHD) represents a severe, T cell-driven inflammatory complication following allogeneic hematopoietic cell transplantation (allo-HCT). GVHD often affects the intestine and is associated with a poor prognosis. Although frequently detectable, proinflammatory mechanisms exerted by intestinal tissue-infiltrating Th cell subsets remain to be fully elucidated. Here, we ...

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