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Multicenter pilot study of radiochemotherapy as first-line treatment for adults with medulloblastoma (NOA-07)

Beier, Dagmar ; Proescholdt, Martin ; Reinert, Christiane ; Pietsch, Torsten ; Jones, David T. W. ; Pfister, Stefan M. ; Hattingen, Elke ; Seidel, Clemens ; Dirven, Linda ; Luerding, Ralf ; Reijneveld, Jaap ; Warmuth-Metz, Monika ; Bonsanto, Matteo ; Bremer, Michael ; Combs, Stephanie E. ; Rieken, Stefan ; Herrlinger, Ulrich ; Kuntze, Holger ; Mayer-Steinacker, Regine ; Moskopp, Dag ; Schneider, Thomas ; Beringer, Andreas ; Schlegel, Uwe ; Stummer, Walter ; Welker, Helmut ; Weyerbrock, Astrid ; Paulsen, Frank ; Rutkowski, Stefan ; Weller, Michael ; Wick, Wolfgang ; Kortmann, Rolf-Dieter ; Bogdahn, Ulrich ; Hau, Peter



Abstract

Background. Medulloblastoma in adult patients is rare, with 0.6 cases per million. Prognosis depends on clinical factors and medulloblastoma entity. No prospective data on the feasibility of radiochemotherapy exist. The German Neuro-Oncology Working Group (NOA) performed a prospective descriptive multicenter single-arm phase II trial to evaluate feasibility and toxicity of radio-polychemotherapy. ...

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