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Contribution of TMEM16F to pyroptotic cell death

Ousingsawat, Jiraporn ; Wanitchakool, Podchanart ; Schreiber, Rainer ; Kunzelmann, Karl



Abstract

Pyroptosis is a highly inflammatory form of programmed cell death that is caused by infection with intracellular pathogens and activation of canonical or noncanonical inflammasomes. The purinergic receptor P2X(7) is activated by the noncanonical inflammasome and contributes essentially to pyroptotic cell death. The Ca2+ activated phospholipid scramblase and ion channel TMEM16F has been shown ...

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