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Diagnostic pathology of early systemic cancer:ERBB2gene amplification in single disseminated cancer cells determines patient survival in operable esophageal cancer

Hoffmann, Martin ; Pasch, Sophie ; Schamberger, Thomas ; Maneck, Matthias ; Möhlendick, Birte ; Schumacher, Sarah ; Brockhoff, Gero ; Knoefel, Wolfram Trudo ; Izbicki, Jakob ; Polzer, Bernhard ; Stoecklein, Nikolas H. ; Klein, Christoph A.



Abstract

Early metastatic dissemination and evolution of disseminated cancer cells (DCCs) outside the primary tumor is one reason for the failure of adjuvant therapies because it generates molecular genotypes and phenotypes different from primary tumors, which still underlie therapy decisions. Since ERBB2 amplification in esophageal DCCs but not in primary tumor cells predict outcome, we aimed to ...

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