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Sox8 and Sox10 jointly maintain myelin gene expression in oligodendrocytes

Turnescu, Tanja ; Arter, Juliane ; Reiprich, Simone ; Tamm, Ernst R. ; Waisman, Ari ; Wegner, Michael



Abstract

In Schwann cells of the vertebrate peripheral nervous system, induction of myelination and myelin maintenance both depend on the HMG-domain-containing transcription factor Sox10. In oligodendrocytes of the central nervous system, Sox10 is also essential for the induction of myelination. Its role in late phases of myelination and myelin maintenance has not been studied so far. Here, we show that ...

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