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Functional phenotypes determined by fluctuation-based clustering of lung function measurements in healthy and asthmatic cohort participants

Delgado-Eckert, Edgar ; Fuchs, Oliver ; Kumar, Nitin ; Pekkanen, Juha ; Dalphin, Jean-Charles ; Riedler, Josef ; Lauener, Roger ; Kabesch, Michael ; Kupczyk, Maciej ; Dahlen, Sven-Erik ; Mutius, Erika von ; Frey, Urs


Rationale Asthma is characterised by inflammation and reversible airway obstruction. However, these features are not always closely related. Fluctuations of daily lung function contain information on asthma phenotypes, exacerbation risk and response to long-acting-agonists. Objectives In search of subgroups of asthmatic participants with specific lung functional features, we developed and ...


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