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Improvement of cardiomyocyte function by a novel pyrimidine-based CaMKII-inhibitor

Neef, Stefan ; Steffens, Alexander ; Pellicena, Patricia ; Mustroph, Julian ; Lebek, Simon ; Ort, Katharina R. ; Schulman, Howard ; Maier, Lars S.



Zusammenfassung

Objective: Pathologically increased activity of Ca2+/calmodulin-dependent protein kinase II (CaMKII) and the associated Ca2+-leak from the sarcoplasmic reticulum are recognized to be important novel pharmacotherapeutic targets in heart failure and cardiac arrhythmias. However, CaMKII-inhibitory compounds for therapeutic use are still lacking. We now report on the cellular and molecular effects of ...

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