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Diagnosis and severity criteria for sinusoidal obstruction syndrome/veno-occlusive disease in pediatric patients: a new classification from the European society for blood and marrow transplantation

Corbacioglu, Selim ; Carreras, E. ; Ansari, M. ; Balduzzi, A. ; Cesaro, S. ; Dalle, J.-H. ; Dignan, F. ; Gibson, B. ; Guengoer, T. ; Gruhn, B. ; Lankester, A. ; Locatelli, F. ; Pagliuca, A. ; Peters, C. ; Richardson, P. G. ; Schulz, A. S. ; Sedlacek, P. ; Stein, J. ; Sykora, K.-W. ; Toporski, J. ; Trigoso, E. ; Vetteranta, K. ; Wachowiak, J. ; Wallhult, E. ; Wynn, R. ; Yaniv, I. ; Yesilipek, A. ; Mohty, M. ; Bader, P.



Abstract

The advances in hematopoietic cell transplantation (HCT) over the last decade have led to a transplant-related mortality below 15%. Hepatic sinusoidal obstruction syndrome/veno-occlusive disease (SOS/VOD) is a life-threatening complication of HCT that belongs to a group of diseases increasingly identified as transplant-related, systemic endothelial diseases. In most cases, SOS/VOD resolves within ...

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