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CFTR supports cell death through ROS-dependent activation of TMEM16F (anoctamin 6)

Simões, Filipa ; Ousingsawat, Jiraporn ; Wanitchakool, Podchanart ; Fonseca, Ana ; Cabrita, Inês ; Benedetto, Roberta ; Schreiber, Rainer ; Kunzelmann, Karl



Abstract

Cystic fibrosis transmembrane conductance regulator (CFTR) is the essential chloride and bicarbonate channel in the apical membrane of epithelial cells. CFTR was also proposed earlier to conduct glutathione (GSH) out of airway epithelial cells to be enriched in the apical airway surface liquid to neutralize reactive oxygen species (ROS). Although earlier studies suggested that release of GSH by ...

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