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Drosophila Sister-of-Sex-lethal is a repressor of translation

Moschall, Rebecca ; Strauss, Daniela ; García-Beyaert, Marina ; Gebauer, Fátima ; Medenbach, Jan


The RNA-binding protein Sex-lethal (Sxl) is an important post-transcriptional regulator of sex determination and dosage compensation in female Drosophila. To prevent the assembly of the MSL dosage compensation complex in female flies, Sxl acts as a repressor of male-specific lethal-2 (msl-2) mRNA translation. It uses two distinct and mutually reinforcing blocks to translation that operate on the ...


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