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Phenotypic dissection of the mouse Ren1d knockout by complementation with human renin

Buckley, Charlotte ; Nelson, Robert J. ; Mullins, Linda J. ; Sharp, Matthew G.F. ; Fleming, Stewart ; Kenyon, Christopher J. ; Semprini, Sabrina ; Steppan, Dominik ; Peti-Peterdi, Janos ; Kurtz, Armin ; Christian, Helen ; Mullins, John J.



Abstract

Normal renin synthesis and secretion is important for the maintenance of juxtaglomerular apparatus architecture. Mice lacking a functional Ren1d gene are devoid of renal juxtaglomerular cell granules and exhibit an altered macula densa morphology. Due to the species-specificity of renin activity, transgenic mice are ideal models for experimentally investigating and manipulating expression ...

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