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Efficacy of MEK inhibition in a K-Ras-driven cholangiocarcinoma preclinical model

Dong, Mingjie ; Liu, Xianqiong ; Evert, Katja ; Utpatel, Kirsten ; Peters, Michele ; Zhang, Shanshan ; Xu, Zhong ; Che, Li ; Cigliano, Antonio ; Ribback, Silvia ; Dombrowski, Frank ; Cossu, Antonio ; Gordan, John ; Calvisi, Diego F. ; Evert, Matthias ; Liu, Yan ; Chen, Xin



Abstract

Intrahepatic cholangiocarcinoma (iCCA) is a deadly malignancy with limited treatment options. Gain-of-function mutations in K-Ras is a very frequent alteration, occurring in similar to 15 to 25% of human iCCA patients. Here, we established a new iCCA model by expressing activated forms of Notch1 (NICD) and K-Ras (K-Ras(V12D)) in the mouse liver (K-Ras/NICD mice). Furthermore, we investigated the ...

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