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Minimum Information about T Regulatory Cells: A Step toward Reproducibility and Standardization

Fuchs, Anke ; Gliwiński, Mateusz ; Grageda, Nathali ; Spiering, Rachel ; Abbas, Abul K. ; Appel, Silke ; Bacchetta, Rosa ; Battaglia, Manuela ; Berglund, David ; Blazar, Bruce ; Bluestone, Jeffrey A. ; Bornhäuser, Martin ; ten Brinke, Anja ; Brusko, Todd M. ; Cools, Nathalie ; Cuturi, Maria Cristina ; Geissler, Edward ; Giannoukakis, Nick ; Gołab, Karolina ; Hafler, David A. ; van Ham, S. Marieke ; Hester, Joanna ; Hippen, Keli ; Di Ianni, Mauro ; Ilic, Natasa ; Isaacs, John ; Issa, Fadi ; Iwaszkiewicz-Grześ, Dorota ; Jaeckel, Elmar ; Joosten, Irma ; Klatzmann, David ; Koenen, Hans ; van Kooten, Cees ; Korsgren, Olle ; Kretschmer, Karsten ; Levings, Megan ; Marek-Trzonkowska, Natalia Maria ; Martinez-Llordella, Marc ; Miljkovic, Djordje ; Mills, Kingston H.G. ; Miranda, Joana P. ; Piccirillo, Ciriaco A. ; Putnam, Amy L. ; Ritter, Thomas ; Roncarolo, Maria Grazia ; Sakaguchi, Shimon ; Sánchez-Ramón, Silvia ; Sawitzki, Birgit ; Sofronic-Milosavljevic, Ljiljana ; Sykes, Megan ; Tang, Qizhi ; Vives-Pi, Marta ; Waldmann, Herman ; Witkowski, Piotr ; Wood, Kathryn J. ; Gregori, Silvia ; Hilkens, Catharien M. U. ; Lombardi, Giovanna ; Lord, Phillip ; Martinez-Caceres, Eva M. ; Trzonkowski, Piotr



Abstract

Cellular therapies with CD4+ T regulatory cells (Tregs) hold promise of efficacious treatment for the variety of autoimmune and allergic diseases as well as posttransplant complications. Nevertheless, current manufacturing of Tregs as a cellular medicinal product varies between different laboratories, which in turn hampers precise comparisons of the results between the studies performed. While ...

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