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A Promising New Approach for the Treatment of Inflammatory Pain: Transfer of Stem Cell-Derived Tyrosine Hydroxylase-Positive Cells

Ebbinghaus, Matthias ; Jenei-Lanzl, Zsuzsa ; Segond von Banchet, Gisela ; Stangl, Hubert ; Gajda, Mieczyslaw ; Straub, Rainer H. ; Schaible, Hans-Georg


Objectives: The appearance of endogenous tyrosine hydroxylase-positive cells (TH+ cells) in collagen-induced arthritis was associated with an anti-inflammatory effect. Here we investigated putative anti-inflammatory and antinociceptive effects of the transfer of induced, bone marrow stem cell-derived TH+ cells (iTH(+) cells) on murine antigen-induced arthritis (AIA). Methods: Bone marrow-derived ...


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