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Phenalen-1-One-Mediated Antimicrobial Photodynamic Therapy and Chlorhexidine Applied to a Novel Caries Biofilm Model

Cieplik, Fabian ; Wimmer, Fabian ; Muehler, Denise ; Thurnheer, Thomas ; Belibasakis, Georgios N. ; Hiller, Karl-Anton ; Maisch, Tim ; Buchalla, Wolfgang



Abstract

Antimicrobial photodynamic therapy (aPDT) may be useful as a supportive antimicrobial measure for caries-active subjects. In this study, the antimicrobial efficacy of aPDT with a phenalen-1-one photosensitizer was evaluated in a novel in vitro biofilm model comprising Actinomyces naeslundii, Actinomyces odontolyticus, and Streptococcus mutans and was compared to chlorhexidine. The proposed ...

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