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P53 Codon 72 Polymorphism and Risk for Squamous Cell Carcinoma of the Penis: A Caucasian Case-Control Study

Stoehr, Robert ; Weisser, Rebecca ; Wendler, Olaf ; Giedl, Johannes ; Daifalla, Khalid ; Gaisa, Nadine T. ; Richter, Georg ; Campean, Valentina ; Burger, Maximilian ; Wullich, Bernd ; Hartmann, Arndt


Squamous cell carcinoma of the penis is a rare but often aggressive disease. A large proportion of penile cancers are associated with HPV infection, mainly with HPV high-risk subtypes 16 and 18. From other HPV-related malignancies a link between a functional SNP in the p53 gene (rs1042522, p.Arg72Pro) and a higher disease risk in the presence of HPV is documented. The p53 p.Arg72 variant was ...


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