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Hypertonicity-imposed BCL-XL addiction primes colorectal cancer cells for death

Heimer, Sina ; Knoll, Gertrud ; Steixner, Charlotte ; Calance, Diana Nicoleta ; Trinh, Dieu Thuy ; Ehrenschwender, Martin



Abstract

Induction of mitochondria-controlled (intrinsic) apoptosis is a mainstay of current anti-neoplastic chemotherapies. Activation of this death pathway is counteracted by BCL-2-like proteins, which functionally set the threshold for apoptosis and determine whether malignant cells are sensitive or resistant to anti-cancer treatments. Hence, unlocking the intrinsic apoptotic cascade and promoting the ...

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