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Evolution of melanoma cross-resistance to CD8+ T cells and MAPK inhibition in the course of BRAFi treatment

Pieper, Natalia ; Zaremba, Anne ; Leonardelli, Sonia ; Harbers, Franziska Noelle ; Schwamborn, Marion ; Lübcke, Silke ; Schrörs, Barbara ; Baingo, Jolanthe ; Schramm, Alexander ; Haferkamp, Sebastian ; Seifert, Ulrike ; Sucker, Antje ; Lennerz, Volker ; Wölfel, Thomas ; Schadendorf, Dirk ; Schilling, Bastian ; Paschen, Annette ; Zhao, Fang


The profound but frequently transient clinical responses to BRAF(V600) inhibitor (BRAFi) treatment in melanoma emphasize the need for combinatorial therapies. Multiple clinical trials combining BRAFi and immunotherapy are under way to further enhance therapeutic responses. However, to which extent BRAF(V600) inhibition may affect melanoma immunogenicity over time remains largely unknown. To ...


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