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SUMO Modification of the RNA-Binding Protein La Regulates Cell Proliferation and STAT3 Protein Stability

Kota, Venkatesh ; Sommer, Gunhild ; Hazard, E. Starr ; Hardiman, Gary ; Twiss, Jeffery L. ; Heise, Tilman



Abstract

The cancer-associated RNA-binding protein La is posttranslationally modified by phosphorylation and sumoylation. Sumoylation of La regulates not only the trafficking of La in neuronal axons but also its association with specific mRNAs. Depletion of La in various types of cancer cell lines impairs cell proliferation; however, the molecular mechanism whereby La supports cell proliferation is not ...

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