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Rapamycin Prolongs Graft Survival and Induces CD4+IFN-γ+IL-10+ Regulatory Type 1 Cells in Old Recipient Mice

Quante, Markus ; Heinbokel, Timm ; Edtinger, Karoline ; Minami, Koichiro ; Uehara, Hirofumi ; Nian, Yeqi ; Azuma, Haruhito ; Abdi, Reza ; Elkhal, Abdallah ; Tullius, Stefan G.


Background. Although the elderly represents a rapidly growing population among transplant recipients, age-specific aspects have not been considered sufficiently in clinical trials. Moreover, age-specific effects of immunosuppressive therapies remain poorly understood. Methods. Here, we assessed the impact of rapamycin on alloimmune responses in old recipients using a fully major ...


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