Endothelin receptors in renal interstitial cells do not contribute to the development of fibrosis during experimental kidney disease

URN to cite this document:: urn:nbn:de:bvb:355-epub-477707
DOI to cite this document:: 10.5283/epub.47770

Neder, Thomas H. ; Schrankl, Julia ; Fuchs, Michaela A. A. ; Broeker, Katharina A. E. ; Wagner, Charlotte

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Date of publication of this fulltext: 10 Aug 2021 12:09

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Abstract

Renal interstitial fibrosis is characterized by the development of myofibroblasts, originating from resident renal and immigrating cells. Myofibroblast formation and extracellular matrix production during kidney damage are triggered by various factors. Among these, endothelins have been discussed as potential modulators of renal fibrosis. Utilizing mouse models of adenine nephropathy (AN) and ...