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Spatial Distribution of a Porphyrin-Based Photosensitizer Reveals Mechanism of Photodynamic Inactivation of Candida albicans

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Voit, Thomas ; Cieplik, Fabian ; Regensburger, Johannes ; Hiller, Karl-Anton ; Gollmer, Anita ; Buchalla, Wolfgang ; Maisch, Tim
License: Creative Commons Attribution 4.0
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Date of publication of this fulltext: 13 Aug 2021 16:18


The antimicrobial photodynamic therapy (aPDT) is a promising approach for the control of microbial and especially fungal infections such as mucosal mycosis. TMPyP [5,10,15, 20-tetrakis(1-methylpyridinium-4-yl)-porphyrin tetra p-toluenesulfonate] is an effective photosensitizer (PS) that is commonly used in aPDT. The aim of this study was to examine the localization of TMPyP in Candida albicans ...


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