De Simone, Gabriele ; Mazza, Emilia M. C. 
; Cassotta, Antonino ; Davydov, Alexey N. ; Kuka, Mirela ; Zanon, Veronica ; De Paoli, Federica ; Scamardella, Eloise ; Metsger, Maria ; Roberto, Alessandra ; Pilipow, Karolina ; Colombo, Federico S. ; Tenedini, Elena ; Tagliafico, Enrico ; Gattinoni, Luca ; Mavilio, Domenico ; Peano, Clelia ; Price, David A. ; Singh, Satya P. ; Farber, Joshua M. ; Serra, Valentina ; Cucca, Francesco ; Ferrari, Francesco ; Orrù, Valeria ; Fiorillo, Edoardo ; Iannacone, Matteo ; Chudakov, Dmitriy M. ; Sallusto, Federica ; Lugli, Enrico
; Cassotta, Antonino ; Davydov, Alexey N. ; Kuka, Mirela ; Zanon, Veronica ; De Paoli, Federica ; Scamardella, Eloise ; Metsger, Maria ; Roberto, Alessandra ; Pilipow, Karolina ; Colombo, Federico S. ; Tenedini, Elena ; Tagliafico, Enrico ; Gattinoni, Luca ; Mavilio, Domenico ; Peano, Clelia ; Price, David A. ; Singh, Satya P. ; Farber, Joshua M. ; Serra, Valentina ; Cucca, Francesco ; Ferrari, Francesco ; Orrù, Valeria ; Fiorillo, Edoardo ; Iannacone, Matteo ; Chudakov, Dmitriy M. ; Sallusto, Federica ; Lugli, Enrico 
Abstract
In mice, the ability of naive T (T-N) cells to mount an effector response correlates with TCR sensitivity for self-derived Ags, which can be quantified indirectly by measuring surface expression levels of CD5. Equivalent findings have not been reported previously in humans. We identified two discrete subsets of human CD8(+) T-N cells, defined by the absence or presence of the chemokine receptor ...
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