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The impact of fluorescein-guided technique in the surgical removal of CNS tumors in a pediatric population: results from a multicentric observational study

de Laurentis, Camilla ; Höhne, Julius ; Cavallo, Claudio ; Restelli, Francesco ; Falco, Jacopo ; Broggi, Morgan ; Bosio, Lorenzo ; Vetrano, Ignazio G. ; Schiariti, Marco ; Zattra, Costanza M. ; Ferroli, Paolo ; Schebesch, Karl-Michael ; Acerbi, Francesco



Abstract

BACKGROUND: Surgery has a fundamental role in central nervous system (CNS) tumors in the pediatric population, as aggressive resection correlates with prognosis. Due to its accumulation in areas with damaged blood brain barrier, sodium fluorescein (SF) could be a valid tool to improve the extent of resection in tumors enhancing at preoperative MRI. This study is aimed to systematically assess the ...

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