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Systemic ß adrenergic stimulation/ sympathetic nerve system stimulation influences intraocular RAS through cAMP in the RPE

Martins, Joana Raquel ; Reichhart, Nadine ; Kociok, Norbert ; Stindl, Julia ; Foeckler, Renate ; Lachmann, Peter ; Todorov, Vladimir ; Castrop, Hayo ; Strauß, Olaf


Several lines of evidence support the existence of a renin-angiotensin system (RAS) in the retina that is separated from the blood stream by the retinal pigment epithelium (RPE). Under physiological conditions, increased activity of intraretinal RAS regulates neuronal activity of the retina but patho-physiologically participates in retinal degeneration such as hypertensive or diabetic ...


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