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Axis inhibition protein 1 (Axin1) Deletion–Induced Hepatocarcinogenesis Requires Intact β‐Catenin but Not Notch Cascade in Mice

Qiao, Yu ; Wang, Jingxiao ; Karagoz, Eylul ; Liang, Binyong ; Song, Xinhua ; Shang, Runze ; Evert, Katja ; Xu, Meng ; Che, Li ; Evert, Matthias ; Calvisi, Diego F. ; Tao, Junyan ; Wang, Bruce ; Monga, Satdarshan P. ; Chen, Xin


Inactivating mutations of axis inhibition protein 1 (AXIN1), a negative regulator of the Wnt/beta-Catenin cascade, are among the common genetic events in human hepatocellular carcinoma (HCC), affecting approximately 10% of cases. In the present manuscript, we sought to define the genetic crosstalk between Axin1 mutants and Wnt/beta-catenin as well as Notch signaling cascades along ...


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