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Lactose drives Enterococcus expansion to promote graft-versus-host disease

Stein-Thoeringer, C. K. ; Nichols, K. B. ; Lazrak, A. ; Docampo, M. D. ; Slingerland, A. E. ; Slingerland, J. B. ; Clurman, A. G. ; Armijo, G. ; Gomes, A. L. C. ; Shono, Y. ; Staffas, A. ; Burgos da Silva, M. ; Devlin, S. M. ; Markey, K. A. ; Bajic, D. ; Pinedo, R. ; Tsakmaklis, A. ; Littmann, E. R. ; Pastore, A. ; Taur, Y. ; Monette, S. ; Arcila, M. E. ; Pickard, A. J. ; Maloy, M. ; Wright, R. J. ; Amoretti, L. A. ; Fontana, E. ; Pham, D. ; Jamal, M. A. ; Weber, D. ; Sung, A. D. ; Hashimoto, D. ; Scheid, C. ; Xavier, J. B. ; Messina, J. A. ; Romero, K. ; Lew, M. ; Bush, A. ; Bohannon, L. ; Hayasaka, K. ; Hasegawa, Y. ; Vehreschild, M. J. G. T. ; Cross, J. R. ; Ponce, D. M. ; Perales, M. A. ; Giralt, S. A. ; Jenq, R. R. ; Teshima, T. ; Holler, E. ; Chao, N. J. ; Pamer, E. G. ; Peled, J. U. ; van den Brink, M. R. M.



Abstract

Disruption of intestinal microbial communities appears to underlie many human illnesses, but the mechanisms that promote this dysbiosis and its adverse consequences are poorly understood. In patients who received allogeneic hematopoietic cell transplantation (allo-HCT), we describe a high incidence of enterococcal expansion, which was associated with graft-versus-host disease (GVHD) and ...

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