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Karyopherin α2-dependent import of E2F1 and TFDP1 maintains protumorigenic stathmin expression in liver cancer

Drucker, Elisabeth ; Holzer, Kerstin ; Pusch, Stefan ; Winkler, Juliane ; Calvisi, Diego F. ; Eiteneuer, Eva ; Herpel, Esther ; Goeppert, Benjamin ; Roessler, Stephanie ; Ori, Alessandro ; Schirmacher, Peter ; Breuhahn, Kai ; Singer, Stephan



Abstract

Background: Members of the karyopherin superfamily serve as nuclear transport receptors/adaptor proteins and provide exchange of macromolecules between the nucleo- and cytoplasm. Emerging evidence suggests a subset of karyopherins to be dysregulated in hepatocarcinogenesis including karyopherin-alpha 2 (KPNA2). However, the functional and regulatory role of KPNA2 in liver cancer remains ...

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