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Substrate stiffness affects the morphology and gene expression of epidermal neural crest stem cells in a short term culture

Pandamooz, Sareh ; Jafari, Arman ; Salehi, Mohammad S. ; Jurek, Benjamin ; Ahmadiani, Abolhassan ; Safari, Anahid ; Hassanajili, Shadi ; Borhani‐Haghighi, Afshin ; Dianatpour, Mehdi ; Niknejad, Hassan ; Azarpira, Negar ; Dargahi, Leila


According to the intrinsic plasticity of stem cells, controlling their fate is a critical issue in cell-based therapies. Recently, a growing body of evidence has suggested that substrate stiffness can affect the fate decisions of various stem cells. Epidermal neural crest stem cells as one of the main neural crest cell derivatives hold great promise for cell therapies due to presenting a high ...


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