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SNAI1 promotes the cholangiocellular phenotype, but not epithelial-mesenchymal transition, in a murine hepatocellular carcinoma model

Xu, Meng ; Wang, Jingxiao ; Xu, Zhong ; Li, Rong ; Wang, Pan ; Shang, Runze ; Cigliano, Antonio ; Ribback, Silvia ; Solinas, Antonio ; Pes, Giovanni Mario ; Evert, Katja ; Wang, Haichuan ; Song, Xinhua ; Zhang, Shu ; Che, Li ; Pascale, Rosa Maria ; Calvisi, Diego F ; Liu, Qingguang ; Chen, Xin


Hepatocellular carcinoma (HCC) is the most common type of liver cancer and has limited treatment options. Snail family transcriptional repressor 1 (SNAI1) is a master regulator of epithelial-mesenchymal transition (EMT) and has been implicated in HCC initiation and progression. However, the precise role of SNAI1 and the way it contributes to hepatocarcinogenesis have not been investigated in ...


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