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Safety and immunogenicity of a multivalent HIV vaccine comprising envelope protein with either DNA or NYVAC vectors (HVTN 096): a phase 1b, double-blind, placebo-controlled trial

Pantaleo, Giuseppe ; Janes, Holly ; Karuna, Shelly ; Grant, Shannon ; Ouedraogo, G. Laissa ; Allen, Mary ; Tomaras, Georgia D. ; Frahm, Nicole ; Montefiori, David C. ; Ferrari, Guido ; Ding, Song ; Lee, Carter ; Robb, Merlin L. ; Esteban, Mariano ; Wagner, Ralf ; Bart, Pierre-Alexandre ; Rettby, Nils ; McElrath, M. Juliana ; Gilbert, Peter B. ; Kublin, James G. ; Corey, Lawrence



Zusammenfassung

Background Up to now, immunisation regimens that have been assessed for development of HIV vaccines have included purified envelope (Env) protein among the boosting components of the regimen. We postulated that co-administration of Env protein with either a DNA or NYVAC vector during priming would result in early generation of antibody responses to the Env V1/V2 region, which are important ...

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