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Aspergillusspecific nestedPCRfrom the site of infection is superior to testing concurrent blood samples in immunocompromised patients with suspected invasive aspergillosis

Boch, Tobias ; Spiess, Birgit ; Heinz, Werner ; Cornely, Oliver A. ; Schwerdtfeger, Rainer ; Hahn, Joachim ; Krause, Stefan W. ; Duerken, Matthias ; Bertz, Hartmut ; Reuter, Stefan ; Kiehl, Michael ; Claus, Bernd ; Deckert, Peter Markus ; Hofmann, Wolf‐Karsten ; Buchheidt, Dieter ; Reinwald, Mark



Zusammenfassung

Invasive aspergillosis (IA) is a severe complication in immunocompromised patients. Early diagnosis is crucial to decrease its high mortality, yet the diagnostic gold standard (histopathology and culture) is time-consuming and cannot offer early confirmation of IA. Detection of IA by polymerase chain reaction (PCR) shows promising potential. Various studies have analysed its diagnostic ...

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