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Quantitative Lipidomics in Pulmonary Alveolar Proteinosis

Griese, Matthias ; Bonella, Francesco ; Costabel, Ulrich ; de Blic, Jacques ; Tran, Nguyen-Binh ; Liebisch, Gerhard


Rationale: Pulmonary alveolar proteinosis (PAP) is characterized by filling of the alveolar spaces by lipoprotein-rich material of ill-defined composition, and is caused by molecularly different and often rare diseases that occur from birth to old age. Objectives: To perform a quantitative lipidomic analysis of lipids and the surfactant proteins A, B, and C in lavage fluids from patients with ...


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