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Loss of Fbxw7 synergizes with activated Akt signaling to promote c-Myc dependent cholangiocarcinogenesis

Wang, Jingxiao ; Wang, Haichuan ; Peters, Michele ; Ding, Ning ; Ribback, Silvia ; Utpatel, Kirsten ; Cigliano, Antonio ; Dombrowski, Frank ; Xu, Meng ; Chen, Xinyan ; Song, Xinhua ; Che, Li ; Evert, Matthias ; Cossu, Antonio ; Gordan, John ; Zeng, Yong ; Chen, Xin ; Calvisi, Diego F.



Abstract

Background & Aims: The ubiquitin ligase F-box and WD repeat domain-containing 7 (FBXW7) is recognized as a tumor suppressor in many cancer types due to its ability to promote the degradation of numerous oncogenic target proteins. Herein, we aimed to elucidate its role in intrahepatic cholangiocarcinoma (iCCA). Methods: Herein, we first confirmed that FBXW7 gene expression was reduced in human ...

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