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“Verteporfin exhibits anti-proliferative activity in embryonal and alveolar rhabdomyosarcoma cell lines”

Sanna, Luca ; Piredda, Roberta ; Marchesi, Irene ; Bordoni, Valentina ; Forcales, Sonia Vanina ; Calvisi, Diego Francesco ; Bagella, Luigi



Abstract

Rhabdomyosarcoma (RMS) is a pediatric tumor, which arises from muscle precursor cells. Recently, it has been demonstrated that Hippo Pathway (Hpo), a pathway that regulates several physiological and biological features, is involved in RMS tumorigenesis. For instance, an upregulation of the Hpo downstream effector Yes-Associated Protein 1 (YAP) leads to the development of embryonal ...

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