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Single cell study of adipose tissue mediated lipid droplet formation and biochemical alterations in breast cancer cells

Blücher, Christina ; Zilberfain, Carolin ; Venus, Tom ; Spindler, Nick ; Dietrich, Arne ; Burkhardt, Ralph ; Stadler, Sonja C. ; Estrela-Lopis, Irina


Obesity is a known risk factor for breast cancer and a negative prognostic factor for cancer recurrence and survival. Several studies demonstrated that aggressive breast tumor cells contain higher numbers of intracellular lipid droplets (LDs). Here we applied simultaneous visualization, identification and quantification of the lipid accumulation in lipid droplets (LDs) of aggressive, human ...


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