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The Transcription Factor Bhlhe40 Programs Mitochondrial Regulation of Resident CD8+ T Cell Fitness and Functionality

Li, Chaofan ; Zhu, Bibo ; Son, Young Min ; Wang, Zheng ; Jiang, Li ; Xiang, Min ; Ye, Zhenqing ; Beckermann, Kathryn E. ; Wu, Yue ; Jenkins, James W. ; Siska, Peter J. ; Vincent, Benjamin G. ; Prakash, Y.S. ; Peikert, Tobias ; Edelson, Brian T. ; Taneja, Reshma ; Kaplan, Mark H. ; Rathmell, Jeffrey C. ; Dong, Haidong ; Hitosugi, Taro ; Sun, Jie



Zusammenfassung

Tissue-resident memory CD8(+) T (Trm) cells share core residency gene programs with tumor-infiltrating lymphocytes (TILs). However, the transcriptional, metabolic, and epigenetic regulation of Trm cell and TIL development and function is largely undefined. Here, we found that the transcription factor Bhlhe40 was specifically required for Trm cell and TIL development and polyfunctionality. Local ...

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