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A transplantable tumor model allowing investigation of NY-BR-1-specific T cell responses in HLA-DRB1*0401 transgenic mice

Das, Krishna ; Eisel, David ; Vormehr, Mathias ; Müller-Decker, Karin ; Hommertgen, Adriane ; Jäger, Dirk ; Zörnig, Inka ; Feuerer, Markus ; Kopp-Schneider, Annette ; Osen, Wolfram ; Eichmüller, Stefan B.


Background NY-BR-1 has been described as a breast cancer associated differentiation antigen with intrinsic immunogenicity giving rise to endogenous T and B cell responses. The current study presents the first murine tumor model allowing functional investigation of NY-BR-1-specific immune responses in vivo. Methods A NY-BR-1 expressing tumor model was established in DR4tg mice based on heterotopic ...


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