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A thyroid hormone network exists in synovial fibroblasts of rheumatoid arthritis and osteoarthritis patients

Pörings, Anna-Sophia ; Lowin, Torsten ; Dufner, Bianca ; Grifka, Joachim ; Straub, Rainer H.



Abstract

While patients with rheumatoid arthritis (RA) sometimes demonstrate thyroidal illness, the role of thyroid hormones in inflamed synovial tissue is unknown. This is relevant because thyroid hormones stimulate immunity, and local cells can regulate thyroid hormone levels by deiodinases (DIO). The study followed the hypothesis that elements of a thyroid hormone network exist in synovial tissue. In ...

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