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IFN-I response timing relative to virus replication determines MERS coronavirus infection outcomes

Channappanavar, Rudragouda ; Fehr, Anthony R. ; Zheng, Jian ; Wohlford-Lenane, Christine ; Abrahante, Juan E. ; Mack, Matthias ; Sompallae, Ramakrishna ; McCray, Paul B. ; Meyerholz, David K. ; Perlman, Stanley


Type 1 IFNs (IFN-I) generally protect mammalian hosts from virus infections, but in some cases, IFN-I is pathogenic. Because IFN-I is protective, it is commonly used to treat virus infections for which no specific approved drug or vaccine is available. The Middle East respiratory syndrome-coronavirus (MERS-CoV) is such an infection, yet little is known about the role of IFN-I in this setting. ...


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