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Systematic characterization of BAF mutations provides insights into intracomplex synthetic lethalities in human cancers

Schick, Sandra ; Rendeiro, André F. ; Runggatscher, Kathrin ; Ringler, Anna ; Boidol, Bernd ; Hinkel, Melanie ; Májek, Peter ; Vulliard, Loan ; Penz, Thomas ; Parapatics, Katja ; Schmidl, Christian ; Menche, Jörg ; Boehmelt, Guido ; Petronczki, Mark ; Müller, André C. ; Bock, Christoph ; Kubicek, Stefan



Abstract

Aberrations in genes coding for subunits of the BRG1/BRM associated factor (BAF) chromatin remodeling complexes are highly abundant in human cancers. Currently, it is not understood how these mostly loss-of-function mutations contribute to cancer development and how they can be targeted therapeutically. The cancer-type-specific occurrence patterns of certain subunit mutations suggest ...

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