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Bedeutung von p16(INK4A) hinsichtlich des Nachweises von HPV-DNA und in der Stratifizierung der tumorspezifischen Mortalität bei 34 Patienten mit invasivem Peniskarzinom in Langzeit-Nachbeobachtung

Bründl, Johannes ; Neppl, Christina ; Hommer, Thomas ; Otto, Wolfgang ; Breyer, Johannes ; Brookman-May, Sabine ; Weber, Florian ; Burger, Maximilian ; May, Matthias ; Eichelberg, Christian



Abstract

Background Human papillomavirus (HPV) infection plays an important role in the pathogenesis of penile squamous cell carcinoma (PSCC) in about one third of the affected patients. Initial data indicate that HPV status could facilitate optimised risk stratification and individualised targeted therapy. The polymerase chain reaction (PCR) assay is the reference method for detection of HPV DNA. It is ...

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