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C-Jun drives melanoma progression in PTEN wild type melanoma cells

Kappelmann-Fenzl, Melanie ; Gebhard, Claudia ; Matthies, Alexander O. ; Kuphal, Silke ; Rehli, Michael ; Bosserhoff, Anja Katrin


Due to the critical impact of active AP-1 transcription factors in melanoma, it is important to define their target genes and to identify and ultimately inhibit oncogenic signals. Here we mapped the genome-wide occupancy of the AP-1 family member c-Jun in different melanoma cells and correlated AP-1 binding with transcriptome data to detect genes in melanoma regulated by c-Jun. Our analysis shows ...


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