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Combined inhibition of Bcl-2 and NFκB synergistically induces cell death in cutaneous T-cell lymphoma

Froehlich, Tabea C. ; Müller-Decker, Karin ; Braun, Jana D. ; Albrecht, Thomas ; Schroeder, Anne ; Gülow, Karsten ; Goerdt, Sergij ; Krammer, Peter H. ; Nicolay, Jan P.



Abstract

Therapeutic options for cutaneous T-cell lymphoma (CTCL) are limited and curative treatment regimens are not available. Thus, new targeted and well-tolerated therapeutic approaches are urgently needed. In this respect, we have recently shown that dimethyl fumerate (DMF) inhibits NF-kappa B acting as a survival factor in CTCL. Similarly, inhibition of the antiapoptotic protein B-cell lymphoma 2 ...

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