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N-chlorotaurine Inactivates Acanthamoeba and Candida albicans in the Porcine Ex Vivo Corneal Infection Model

Teuchner, Barbara ; Wibmer, Idris D. ; Schaumann, Philipp ; Seifarth, Christof ; Walochnik, Julia ; Nagl, Markus


Purpose: N-chlorotaurine (NCT) is an anti-infective belonging to the class of chloramines and an investigative drug for the topical treatment of keratoconjunctivitis. The aim of the present study was to demonstrate its efficacy against Acanthamoeba and Candida in corneas infected ex vivo. Methods: Corneal buttons from porcine eyes were contaminated with Acanthamoeba castellanii trophozoites or ...


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