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Assessment of Novel Genome-Wide Significant Gene Loci and Lesion Growth in Geographic Atrophy Secondary to Age-Related Macular Degeneration

Grassmann, Felix ; Harsch, Sebastian ; Brandl, Caroline ; Kiel, Christina ; Nürnberg, Peter ; Toliat, Mohammad R. ; Fleckenstein, Monika ; Pfau, Maximilian ; Schmitz-Valckenberg, Steffen ; Holz, Frank G. ; Chew, Emily Y. ; Swaroop, Anand ; Ratnapriya, Rinki ; Klein, Michael L. ; Mulyukov, Zufar ; Zamiri, Parisa ; Weber, Bernhard H. F.


Importance Age-related macular degeneration (AMD) is a common threat to vision loss in individuals older than 50 years. While neovascular complications in AMD are treatable, there is currently no therapy for geographic atrophy secondary to AMD. Geographic atrophy lesion progression over time shows considerable interindividual variability, but little is known about prognostic factors. Objective To ...


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