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Randomized phase-II trial evaluating induction therapy with idarubicin and etoposide plus sequential or concurrent azacitidine and maintenance therapy with azacitidine

Schlenk, R. F. ; Weber, D. ; Herr, W. ; Wulf, G. ; Salih, H. R. ; Derigs, H. G. ; Kuendgen, A. ; Ringhoffer, M. ; Hertenstein, B. ; Martens, U. M. ; Grießhammer, M. ; Bernhard, H. ; Krauter, J. ; Girschikofsky, M. ; Wolf, D. ; Lange, E. ; Westermann, J. ; Koller, E. ; Kremers, S. ; Wattad, M. ; Heuser, M. ; Thol, F. ; Göhring, G. ; Haase, D. ; Teleanu, V. ; Gaidzik, V. ; Benner, A. ; Döhner, K. ; Ganser, A. ; Paschka, P. ; Döhner, H.



Abstract

The aim of this randomized phase-II study was to evaluate the effect of substituting cytarabine by azacitidine in intensive induction therapy of patients with acute myeloid leukemia (AML). Patients were randomized to four induction schedules for two cycles: STANDARD (idarubicin, cytarabine, etoposide); and azacitidine given prior (PRIOR), concurrently (CONCURRENT), or after (AFTER) therapy with ...

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