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Pharmacokinetics of venlafaxine in treatment responders and non-responders: a retrospective analysis of a large naturalistic database

Schoretsanitis, Georgios ; Haen, Ekkehard ; Gründer, Gerhard ; Hiemke, Christoph ; Endres, Katharina ; Ridders, Florian ; Correll, Christoph U. ; Paulzen, Michael


PurposeTo assess in a large naturalistic sample, whether clinical response to a treatment with venlafaxine is associated with different patterns of plasma concentrations of active moiety, AM (sum of venlafaxine (VEN) and its active metabolite O-desmethylvenlafaxine (ODVEN)).MethodsApplying a regression model, plasma concentrations and plasma concentrations corrected-by-dosage (C/D) for AM were ...


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