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Mechanosensitive MiRs regulated by anabolic and catabolic loading of human cartilage

Hecht, N. ; Johnstone, B. ; Angele, P. ; Walker, T. ; Richter, W.


Objective: Elucidation of whether miRs are involved in mechanotransduction pathways by which cartilage is maintained or disturbed has a particular importance in our understanding of osteoarthritis (OA) pathophysiology. The aim was to investigate whether mechanical loading influences global miR-expression in human chondrocytes and to identify mechanosensitive miRs responding to beneficial and ...


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