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Chemogenetic activation of oxytocin neurons: Temporal dynamics, hormonal release, and behavioral consequences

Grund, Thomas ; Tang, Yan ; Benusiglio, Diego ; Althammer, Ferdinand ; Probst, Sophia ; Oppenländer, Lena ; Neumann, Inga D. ; Grinevich, Valery



Abstract

Chemogenetics provides cell type-specific remote control of neuronal activity. Here, we describe the application of chemogenetics used to specifically activate oxytocin (OT) neurons as representatives of a unique class of neuroendocrine cells. We injected recombinant adeno-associated vectors, driving the stimulatory subunit hM3Dq of a modified human muscarinic receptor into the rat hypothalamus ...

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